id |
{trials, registrations, results} Unique trial identifier |
character |
n_trn |
{registrations} Count of trial registration numbers for a trial |
numeric |
source |
{registrations} Source of trial registration number: `ictrp` (i.e., WHO ICTRP), `auto` (i.e., found via automated searches on registry or in Trials Tracker), `reg` (i.e., found on registry via manual search) |
categorical |
trn |
{registrations} Trial registration number |
character |
registry |
{registrations} Clinical trial registry |
categorical |
trn |
{results} Trial registration number if result associated with trial NOT in dataset. `no TRN found` if no trn reported in result. `see trials` if result associated with trial in dataset. |
character |
search_type |
{results} Type of search used to find result: `results_check` (automated results search in CORD-19 and PubMed), `registry` (summary result or publication citation on registry), `trn` (search engine query using TRN), `keywords` (search engine query using trial keywords) |
categorical |
pub_type |
{results} Publication type. Full results report complete results of the primary outcome(s) for all participants. All other results are interim: `full_results_preprint`, `full_results_journal_article`, `interim_results_journal_article`, `other` (includes protocols, conference abstracts, posters, and presentations, grey literature), `summary_results` (i.e., registry results), `interim_results_preprint`, `interim_result` |
categorical |
search_engine |
{results} Search engine. If `search_type` is `trn` or `keywords`, which search engine was used to find the result: `pubmed`, `europe_pmc`, `google_scholar`, `google` |
categorical |
doi |
{results} Publication DOI |
character |
pmid |
{results} Publication PubMed id |
numeric |
cord_id |
{results} Publication CORD-19 id. Sparsely used. May be removed in future dataset versions. |
character |
url |
{results} Publication URL |
character |
date_publication |
{results} Trial publication date. Earliest available, including online-first. |
date |
date_completion |
{results} Trial completion date (last patient, last visit), if reported in the publication. |
date |
comments |
{results} Comments on results from manual data extraction. |
character |
trialid |
{trials} Preferred trial registration number from input ICTRP dataset after TrialsTracker pre-processing. |
character |
source_register |
{trials} Preferred trial registry from input ICTRP dataset after TrialsTracker pre-processing. |
categorical |
date_registration |
{trials} Trial registration date, per ICTRP. |
date |
date_enrollement |
{trials} Trial first enrollment date, per ICTRP. |
date |
retrospective_registration |
{trials} Whether trial was registered retrospectively, per ICTRP after TrialsTracker pre-processing. Not necessarily the same as "Retrospective flag" on the ICTRP. |
logical |
normed_spon_names |
{trials} Normed sponsor names, derived from the ICTRP. |
character |
recruitment_status |
{trials} Recruitment status, per ICTRP: `Authorised`, `Not Recruiting`, `Recruiting`, `No Status Given` |
categorical |
phase |
{trials} Phase, per ICTRP. Normalized in TrialsTracker pre-processing: `Phase 1`, `Phase 1/Phase 2`, `Phase 2`, `Phase 2/Phase 3`, `Phase 3`, `Phase 3/Phase 4`, `Phase 4`, `Not Applicable`. |
categorical |
study_type |
{trials} Study type, per ICTRP. Normalized in TrialsTracker pre-processing: `Interventional`, `Prevention`, `Observational`, `Diagnostic test`, `Prognosis`, `Basic Science`, `Epidemiological research`, `Health services research`, `Screening`, `Expanded Access`, `Other`, `Unknown`. Only `Interventional` and `Prevention` considered clinical trials. |
categorical |
countries |
{trials} Countries, per ICTRP. |
categorical |
public_title |
{trials} Trial title, per ICTRP. |
character |
study_category |
{trials} Category of intervention or topic of study, based on TrialsTracker schema. Not systematically extracted to date: 39 categories. |
categorical |
intervention |
{trials} Trial interventions, extracted from ICTRP data for TrialsTracker. Not systematically extracted to date. |
character |
intervention_list |
{trials} List of all unique intervention in trial, seperated by a ";", derived from ICTRP. |
character |
target_enrollment |
{trials} Trial target enrollment, extracted and cleaned automatically from ICTRP. |
numeric |
web_address |
{trials} Trial registration URL, per ICTRP. |
character |
trial_status |
{trials} Trial status, per registry during automated screening, if available. Takes the form of a list for the EUCTR to account for multiple protocols. |
categorical |
registry_scraped |
{trials} Whether registry scraped. NA for non-trials. TRUE for trials. No FALSE in first phase. |
logical |
pcd_auto |
{trials} Primary completion date, per registry during automated screening, if available. |
date |
scd_auto |
{trials} Study completion date, per registry during automated screening, if available. |
date |
rcd_auto |
{trials} Relevant completion date, based on automated screening. Used for our trial automated screening criteria. `scd_auto` if available, otherwise `pcd_auto`, otherwise NA. |
date |
tabular_results |
{trials} Whether summary results posted for ClinicalTrial.gov or EUCTR trials. NA is `source_register` is NOT ClinicalTrial.gov or EUCTR. 0 indicates FALSE. No summary results detected in first phase. |
logical |
potential_other_results |
{trials} Whether publication citations posted for ClinicalTrial.gov trials. NA is `source_register` is NOT ClinicalTrial.gov. 0 indicates FALSE. 1 indicates TRUE. |
logical |
has_auto_reg_results_cutoff_1 |
{trials} Whether `tabular_results` or `potential_other_results` detected on registry in automated screening. |
logical |
is_intervention |
{trials} Whether ICTRP `study_type` is `Interventional` or `Prevention`. Used for our trial automated screening criteria. |
logical |
is_reg_2020 |
{trials} Whether ICTRP `date_registration` is as of 2020-01-01. Used for our trial automated screening criteria. |
logical |
is_not_withdrawn |
{trials} Whether not indicated as withdrawn in either ICTRP or registry during automated screening. Used for our trial automated screening criteria. |
logical |
is_eligible_study |
{trials} Whether eligible for manual screening for our study. Based on `is_intervention`, `is_reg_2020`, and `is_not_withdrawn`. |
logical |
is_rcd_cutoff_1 |
{trials} Whether `rcd_auto` on or before phase 1 cutoff of 2020-06-30 |
logical |
is_searched_cutoff_1 |
{trials} Whether included in phase 1 manual search. Based on `is_eligible_study` and either `is_rcd_cutoff_1` or `has_auto_reg_results_cutoff_1`. |
logical |
is_clinical_trial_manual |
{trials} Whether a clinical trial, per manual screening. |
logical |
is_covid_manual |
{trials} Whether the primary outcome of the clinical trial is the treatment or prevention of COVID-19/SARS-COV-2, per manual screening. |
logical |
is_not_withdrawn_manual |
{trials} Whether not indicated as withdrawn on registry during manual screening. |
logical |
pcd_manual |
{trials} Primary completion date, per registry during manual screening, if available. |
date |
scd_manual |
{trials} Study completion date, per registry during manual screening, if available. |
date |
rcd_manual |
{trials} Relevant completion date, based on manual screening. |
date |
is_rcd_cutoff_1_manual |
{trials} Whether `rcd_manual` on or before phase 1 cutoff of 2020-06-30. |
logical |
comments |
{trials} Comments on trials from manual data extraction. |
character |
is_analysis_pop_cutoff_1 |
{trials} Whether included in phase 1 analysis population. Based on `is_eligible_study`, `is_rcd_cutoff_1`, and manual screening (`is_clinical_trial_manual`, `is_covid_manual`, and `is_not_withdrawn_manual`). |
logical |
is_dupe |
{trials} Whether trial is a duplicate in our dataset. Duplicates determined based on cross-registrations found in manual search. 18 duplicates found in phase 1 and excluded from analysis. |
logical |
dupe_primary |
{trials} If trial `is_dupe`, `id` of primary trial. |
character |